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Valproate, Hyperandrogenism, and Polycystic Ovaries Arch Neurol 57:1064-1068, Isojarvi,J.I.T. & Tapanainen,J.S., 2000 See this aricle in Pubmed Article Abstract The 3 cases presented here illustrate the development of reproductive endocrine disorders after the initiation of valproate therapy in women with epilepsy. The disorders were characterized by hyperandrogenism and polycystic ovaries in all cases, and were associated with weight gain and menstrual disorders in 2 of the 3 women. An evaluation of ovarian structure and function should be considered in women of reproductive age being treated with valproate for epilepsy, especially if they develop menstrual cycle disturbances during treatment.

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(click to filter results - removes previous filter) adverse drug reaction amenorrhea anticonvulsants,untoward effects of menses,irregular neuroendocrinology polycystic ovarian syndrome seizure seizure,women sodium valproate testosterone,serum testosterone,serum,elevated weight gain

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